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Since the 1950s, corticosteroids (steroids) have been helping those with ulcerative colitis (UC) put the disease in remission. In 2014, the Food and Drug Administration (FDA) approved the oral cortica drug infliximab for ulcerative colitis in patients with two years or less of remission and in subjects with chronic active ulcerative colitis (CACT), as well as in patients whose other CDI drugs were not approved for that indication. The FDA has also been evaluating infliximab and methotrexate (Harvoni), a non-steroid-based antibiotic, for patients with persistent, severe UC. These trials have shown mixed results. But researchers have recently added an extra ingredient to the list of possible cures for inflammatory bowel disease (IBD): human chondroitin sulfate (chrd). If approved by the FDA, chrd (which is synthesized from chondroitin and zinc) will help the body heal the damage caused by disease. Chrd is an effective supplement that helps slow the progression of disease, but researchers are finding that the compound is able to reverse some of the damage that has occurred during the inflammation it is meant to heal. Chrd's mechanism to heal is to increase cell membranes in the bowel, which are involved in the release of chemicals that help cells heal, or repair, their DNA. In a mouse study, researchers report in the Journal of Agricultural and Food Chemistry that chrd is capable of rapidly reversing intestinal inflammation, while improving gut motility, an indicator of intestinal health. Researchers were able to find that chrd is effective in reversing intestinal inflammation by increasing the amount of enzymes necessary to repair damaged bacteria. Their results show that chrd has the capacity to reverse inflammation in the intestines while simultaneously restoring intestinal motility. Chrd also helped the mice's intestines move more easily, allowing them to get food without causing discomfort. Mice with a history of gut dysfunction, as well as those mice treated with a high dose of chrd, found their intestines to move easier. Chrd has also been shown to be effective in preventing inflammation-associated intestinal damage caused by inflammatory bowel disease (IBD) in rats. This suggests that chrd may be effective in treating IBD. Since chrd is non-steroidal, therefore non-toxic, the benefit is likely to go beyond the benefit of the dietary product alone. Given that people with IBD often have very short periods of remission and are in a constant state of disease, chrd may give those with IBD relief of some Similar articles:

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